The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae.
Identifieur interne : 001A65 ( Main/Exploration ); précédent : 001A64; suivant : 001A66The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae.
Auteurs : C. Berset [Suisse] ; H. Trachsel ; M. AltmannSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 1998.
Descripteurs français
- KwdFr :
- ARN messager (métabolisme), Biosynthèse des protéines (MeSH), Cinétique (MeSH), Cycle cellulaire (effets des médicaments et des substances chimiques), Facteur-4A d'initiation eucaryote (MeSH), Facteur-4E d'initiation eucaryote (MeSH), Facteur-4G d'initiation eucaryote (MeSH), Facteurs initiation chaîne peptidique (effets des médicaments et des substances chimiques), Facteurs initiation chaîne peptidique (métabolisme), Facteurs temps (MeSH), Génotype (MeSH), Polyènes (pharmacologie), Saccharomyces cerevisiae (cytologie), Saccharomyces cerevisiae (effets des médicaments et des substances chimiques), Saccharomyces cerevisiae (métabolisme), Sirolimus (MeSH), Transduction du signal (effets des médicaments et des substances chimiques).
- MESH :
- cytologie : Saccharomyces cerevisiae.
- effets des médicaments et des substances chimiques : Cycle cellulaire, Facteurs initiation chaîne peptidique, Saccharomyces cerevisiae, Transduction du signal.
- métabolisme : ARN messager, Facteurs initiation chaîne peptidique, Saccharomyces cerevisiae.
- pharmacologie : Polyènes.
- Biosynthèse des protéines, Cinétique, Facteur-4A d'initiation eucaryote, Facteur-4E d'initiation eucaryote, Facteur-4G d'initiation eucaryote, Facteurs temps, Génotype, Sirolimus.
English descriptors
- KwdEn :
- Cell Cycle (drug effects), Eukaryotic Initiation Factor-4A (MeSH), Eukaryotic Initiation Factor-4E (MeSH), Eukaryotic Initiation Factor-4G (MeSH), Genotype (MeSH), Kinetics (MeSH), Peptide Initiation Factors (drug effects), Peptide Initiation Factors (metabolism), Polyenes (pharmacology), Protein Biosynthesis (MeSH), RNA, Messenger (metabolism), Saccharomyces cerevisiae (cytology), Saccharomyces cerevisiae (drug effects), Saccharomyces cerevisiae (metabolism), Signal Transduction (drug effects), Sirolimus (MeSH), Time Factors (MeSH).
- MESH :
- chemical , drug effects : Peptide Initiation Factors.
- chemical , metabolism : Peptide Initiation Factors, RNA, Messenger.
- chemical , pharmacology : Polyenes.
- chemical : Eukaryotic Initiation Factor-4A, Eukaryotic Initiation Factor-4E, Eukaryotic Initiation Factor-4G, Sirolimus.
- cytology : Saccharomyces cerevisiae.
- drug effects : Cell Cycle, Saccharomyces cerevisiae, Signal Transduction.
- metabolism : Saccharomyces cerevisiae.
- Genotype, Kinetics, Protein Biosynthesis, Time Factors.
Abstract
Initiation factor eIF4G is an essential protein required for initiation of mRNA translation via the 5' cap-dependent pathway. It interacts with eIF4E (the mRNA 5' cap-binding protein) and serves as an anchor for the assembly of further initiation factors. With treatment of Saccharomyces cerevisiae with rapamycin or with entry of cells into the diauxic phase, eIF4G is rapidly degraded, whereas initiation factors eIF4E and eIF4A remain stable. We propose that nutritional deprivation or interruption of the TOR signal transduction pathway induces eIF4G degradation.
DOI: 10.1073/pnas.95.8.4264
PubMed: 9539725
PubMed Central: PMC22477
Affiliations:
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It interacts with eIF4E (the mRNA 5' cap-binding protein) and serves as an anchor for the assembly of further initiation factors. With treatment of Saccharomyces cerevisiae with rapamycin or with entry of cells into the diauxic phase, eIF4G is rapidly degraded, whereas initiation factors eIF4E and eIF4A remain stable. We propose that nutritional deprivation or interruption of the TOR signal transduction pathway induces eIF4G degradation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9539725</PMID><DateCompleted><Year>1998</Year><Month>05</Month><Day>13</Day></DateCompleted><DateRevised><Year>2019</Year><Month>05</Month><Day>01</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0027-8424</ISSN><JournalIssue CitedMedium="Print"><Volume>95</Volume><Issue>8</Issue><PubDate><Year>1998</Year><Month>Apr</Month><Day>14</Day></PubDate></JournalIssue><Title>Proceedings of the National Academy of Sciences of the United States of America</Title><ISOAbbreviation>Proc Natl Acad Sci U S A</ISOAbbreviation></Journal><ArticleTitle>The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae.</ArticleTitle><Pagination><MedlinePgn>4264-9</MedlinePgn></Pagination><Abstract><AbstractText>Initiation factor eIF4G is an essential protein required for initiation of mRNA translation via the 5' cap-dependent pathway. It interacts with eIF4E (the mRNA 5' cap-binding protein) and serves as an anchor for the assembly of further initiation factors. With treatment of Saccharomyces cerevisiae with rapamycin or with entry of cells into the diauxic phase, eIF4G is rapidly degraded, whereas initiation factors eIF4E and eIF4A remain stable. 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